About Us
We develop systems biology approaches to study interactions between cardiomyocytes and cancer cells.
What We Do
We are a dynamic research group at the Smidt Heart Institute with Cedars-Sinai Medical Center.
Our goal is to uncover underlying mechanisms that cause heart failure in cancer using interdisciplinary and computational approaches.
Our model systems include ex vivo heart perfusions, cell cultures and in vivo mouse models.
We have established several techniques including mathematical simulations, stable isotope tracer analysis, and mass spectrometry-based metabolomics.
Research Topics
- Metabolic impact of IDH1 and IDH2 mutations
- Cancer-treatment related cardiotoxicities
- Cachexia
- Mathematical modeling of complex biological systems
- Systems analysis of metabolism
Collaborators
Here are some wonderful scientists that we have the honor of collaborating with.
Cedars Sinai Medical Center
Baylor College of Medicine
- James F. Martin – Department of Molecular Physiology and Biophysics
- Peggy Goodell – Department of Molecular and Cellular Biology
MD Anderson Cancer Center
- David Piwnica-Worms – Department of Cancer Systems Imaging
- Seth T. Gammon – Department of Cancer Systems Imaging
- Philip L. Lorenzi – Metabolomics Facility