Anja Karlstaedt Lab


About Us

We develop systems biology approaches to study interactions between cardiomyocytes and cancer cells.

What We Do

We are a dynamic research group at the Smidt Heart Institute with Cedars-Sinai Medical Center.

Our goal is to uncover underlying mechanisms that cause heart failure in cancer using interdisciplinary and computational approaches.

Our model systems include ex vivo heart perfusions, cell cultures and in vivo mouse models.

We have established several techniques including mathematical simulations, stable isotope tracer analysis, and mass spectrometry-based metabolomics.

Research Topics

  • Metabolic impact of IDH1 and IDH2 mutations
  • Cancer-treatment related cardiotoxicities
  • Cachexia
  • Mathematical modeling of complex biological systems
  • Systems analysis of metabolism

Collaborators

Here are some wonderful scientists that we have the honor of collaborating with.

Cedars Sinai Medical Center

Baylor College of Medicine

MD Anderson Cancer Center

University of California San Francisco

UT Southwestern