2024

Preprint

• Liu S., …Karlstaedt A. ATP-dependent citrate lyase. Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart. bioRxiv [Preprint]. 2024 Jun 21:2024.06.21.600099. doi: 10.1101/2024.06.21.600099.

Peer reviewed

• Gao Y, Kim K, Vitrac H, Salazar RL, Gould BD, Soedkamp D, Spivia W, Raedschelders K, Dinh AQ, Guzman AG, Tan L, Azinas S, Taylor DJR, Schiffer W, McNavish D, Burks HB, Gottlieb RA, Lorenzi PL, Hanson BM, Van Eyk JE, Taegtmeyer H, Karlstaedt A. Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG. Mol Metab. 2024:86:101969. doi: 10.1016/j.molmet.2024.101969.
• Broz MT, Ko EY, Ishaya K, Xiao J, De Simone M, Hoi XP, Piras R, Gala B, Tessaro FHG, Karlstaedt A, Orsulic S, Lund AW, Chan KS, Guarnerio J. Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas. Nature Communications 2024:2498. doi: 10.1038/s41467-024-46504-4.
• Ohanele C, Peoples JN, Karlstaedt A, Geiger JT, Gayle AD, Ghazal N, Sohani F, Brown ME, Davis ME, Porter GA Jr, Faundez V, Kwong JQ. The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart. Commun Biol. 2024:1422. doi: 10.1038/s42003-024-07110-8.
• Amoakon JP, Lee J, Liyanage P, Arora K, Karlstaedt A, Mylavarapu G, Amin R, Naren AP. Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure. iScience. 2024:110703. doi: 10.1016/j.isci.2024.110703.
• Thorp EB, Karlstaedt A. Intersection of Immunology and Metabolism in Myocardial Disease. Circ Res. 2024;134(12):1824-1840. doi: 10.1161/CIRCRESAHA.124.323660.
• Vaniya A, Karlstaedt A, Gulkok D, Thottakara T, Liu Y, Fan S, Eades H, Vakrou S, Fukunaga R, Vernon HJ, Fiehn O, Roselle Abraham M. Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy. J Mol Cell Cardiol Plus. 2024:8:100073. doi: 10.1016/j.jmccpl.2024.100073.
• Figuereido J, Bhowmick N, Karlstaedt A. Metabolic basis of cardiac dysfunction in cancer patients. Current Opinion in Cardiology 2024

2023

• Fenioux C, Abbar B, Boussouar S, Bretagne M, Power JR, Moslehi JJ, Gougis P, Amelin D, Dechartres A, Lehmann LH, Courand PY, Cautela J, Alexandre J, Procureur A, Rozes A, Leonard-Louis S, Qin J; International ICI-Myocarditis Registry; Cheynier R, Charmeteau-De Muylder B, Redheuil A, Tubach F, Cadranel J, Milon A, Ederhy S, Similowski T, Johnson DB, Pizzo I, Catalan T, Benveniste O, Hayek SS, Allenbach Y, Rosenzwajg M, Dolladille C, Salem JE. Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis. Nat Med. 2023 Dec;29(12):3100-3110. PMID: 37884625.
• Tan L, Martinez SA, Lorenzi PL, Karlstaedt A. Quantitative Analysis of Acetyl-CoA, Malonyl-CoA, and Succinyl-CoA in Myocytes. J Am Soc Mass Spectrom. 2023 Nov 1;34(11):2567-2574. doi: 10.1021/jasms.3c00278. Epub 2023 Oct 9. PMID: 37812744.
• Vaniya A, Karlstaedt A, Gulkok DA, Thottakara T, Liu Y, Fan S, Eades H, Fukunaga R, Vernon HJ, Fiehn O, Roselle Abraham M. Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathy. bioRxiv [Preprint]. 2023 PMID: 38014251.
• Ohanele C, Peoples JN, Karlstaedt A, Geiger JT, Gayle AD, Ghazal N, Sohani F, Brown ME, Davis ME, Porter GA, Faundez V, Kwong JQ. Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart. bioRxiv [Preprint]. 2023 PMID: 37292906.

2022

• Karlstaedt A, Moslehi J, de Boer RA. Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer. Nat Rev Cardiol. 2022 Jun;19(6):414-425. 2022 Pubmed

• McClements L, Richards C, Patel N, Chen H, Sesperez K, Bubb KJ, Karlstaedt A, Aksentijevic D. Impact of reduced uterine perfusion pressure model of preeclampsia on metabolism of placenta, maternal and fetal hearts. Sci Rep. 2022;12(1):1111. Pubmed

2021

• Davogustto GE, Salazar RL, Vasquez HG, Karlstaedt A, Dillon WP, Guthrie PH, Martin JR, Vitrac H, De La Guardia G, Vela D, Ribas-Latre A, Baumgartner C, Eckel-Mahan K, Taegtmeyer H. Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021;158:115-127. Pubmed

• Karlstaedt A. Stable Isotopes for Tracing Cardiac Metabolism in DiseaFront Cardiovasc Med. 2021;8:734364. Pubmed

• Karlstaedt A, Barrett M, Hu R, Gammons ST, Ky B. Cardio-Oncology: Understanding the Intersections Between Cardiac Metabolism and Cancer Biology. JACC Basic Transl Sci. 2021;6(8):705-718. Pubmed

2020

• Aksentijević D, Karlstaedt A, Basalay MV, O’Brien BA, Sanchez-Tatay D, Eminaga S, Thakker A, Tennant DA, Fuller W, Eykyn TR, Taegtmeyer H, Shattock MJ. Intracellular sodium elevation reprograms cardiac metabolism. Nat Commun. 2020;11:4337. Pubmed

• Karlstaedt A, Khanna R, Thangam M, Taegtmeyer H. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. Pubmed

2012 – 2019

• Taegtmeyer H, Karlstaedt A, Rees ML, Davogustto G. Oncometabolic Tracks in the Heart.Circ Res. 2017 Jan 20;120(2):267-269. PMID: 28104766

• Taegtmeyer H, Karlstaedt A. Letter by Taegtmeyer and Karlstaedt Regarding Article, “Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors)”. Circulation. 2018 Feb 27;137(9):986-987. PMID: 29483178

• Karlstaedt A, Taegtmeyer H. Letter by Karlstaedt and Taegtmeyer Regarding Article, “Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy”. Circ Res. 2016 Jul 8;119(2):e28. PMID: 27390339

• Vitrac H, MacLean DM, Karlstaedt A, Taegtmeyer H, Jayaraman V, Bogdanov M, Dowhan W. Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation. J Biol Chem. 2017 Feb 3;292(5):1613-1624. PMID: 27974465

• Karlstaedt A, Schiffer W, Taegtmeyer H. Actionable Metabolic Pathways in Heart Failure and Cancer-Lessons From Cancer Cell Metabolism.Front Cardiovasc Med. 2018 Jun 19;5:71. PMID: 29971237

• Garcia MI, Karlstaedt A, Chen JJ, Amione-Guerra J, Youker KA, Taegtmeyer H, Boehning D. Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors. Mol Cell Cardiol. 2017 Nov;112:95-103. PMID: 28923351

• Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H. Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent hear Proc Natl Acad Sci U S A. 2016 Sep 13;113(37). PMID: 27582470

• Rowlett VW, Mallampalli VKPS, Karlstaedt A, Dowhan W, Taegtmeyer H, Margolin W, Vitrac H. Impact of Membrane Phospholipid Alterations in Escherichia coli on Cellular Function and Bacterial Stress Adaptation. J Bacteriol. 2017 Jun 13;199(13):e00849-16. PMID: 28439040